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Second Alzheimer’s drug in the pipeline promises to slow worsening but with safety concern

Published Wed, 27 Nov 2024 09:22:03 GMT

WASHINGTON (AP) — Another experimental Alzheimer’s drug can modestly slow patients’ inevitable worsening — by about four to seven months, researchers reported Monday.Eli Lilly and Co. is seeking Food and Drug Administration approval of donanemab. If cleared, it would be only the second Alzheimer’s treatment convincingly shown to delay the mind-robbing disease — after the recently approved Leqembi from Japanese drugmaker Eisai.“Finally there’s some hope, right, that we can talk about,” Lilly’s Dr. John Sims told reporters Monday at the Alzheimer’s Association International Conference in Amsterdam. “We don’t cure the disease,” he said. “Diabetes doesn’t have a cure either — it doesn’t mean you can’t have very meaningful treatments for patients.”Lilly announced in May that donanemab appeared to work, but on Monday the full results of a study of 1,700 patients was published by the Journal of the American Medical Association and presented a...

Separatist attack kills 10 in northwestern Cameroon, regional governor says

Published Wed, 27 Nov 2024 09:22:03 GMT

YAOUNDE, Cameroon (AP) — Armed separatists wearing military uniforms killed 10 civilians and wounded three in an attack at a crowded intersection in Cameroon’s volatile northwest, the regional governor said on Monday.The killings took place on Sunday in Bamenda, the region’s capital, according to the governor, Debben Tchoffo. The victims included a couple of newlyweds, he said. Eight people died at the scene and two more later in hospital. For the past six years, the protracted armed conflict known as the Anglophone crisis has devastated communities across Cameroon’s two English-speaking regions, officially called Northwest and Southwest, as armed separatists clash with government forces. Following a crackdown on peaceful protests in 2016, armed rebel groups mobilized and vowed to fight for the independence of the Anglophone areas, which they call Ambazonia. Human Rights Watch estimates that as of 2022, at least 4,000 civilians have died and more than 700,000 were displaced by...

Watch: Mike Johnston sworn in as Denver mayor

Published Wed, 27 Nov 2024 09:22:03 GMT

DENVER (KDVR) — On Monday, Denver is set to inaugurate its first new mayor in 12 years, marking a new political era for the Mile High City. The ceremony inaugurating the city’s 46th mayor will happen Monday morning at the Ellie Caulkins Opera House at the Denver Performing Arts Complex. Aurora threatens to cut ties with Denver Police Department Mayor-elect Mike Johnston will take the reins from Mayor Michael Hancock. Last month, voters picked Johnston, a former state senator, in a runoff election. He defeated Kelly Brough, the president and CEO of the Denver Chamber of Commerce. Colorado state Rep. Leslie Herod is Johnston’s inauguration chair.His transition committee includes Ami Desai, the chief operating officer at Gary Community Ventures and an executive director. Co-chairs include former Denver Mayor Federico Peña; state Sen. Julie Gonzales; former Denver Post editor Greg Moore; Downtown Denver Partnership CEO Kourtny Garrett; and organizational and diversity strategist M...

Photos: Fan rushes field during Rockies-Yankees game

Published Wed, 27 Nov 2024 09:22:03 GMT

DENVER (KDVR) — The Colorado Rockies hosted the New York Yankees at Coors Field for the first time since 2016. The three-game series was anything but boring, especially when a fan rushed the field during Saturday's game.In the second game of the series, the Yankees were up 6-2 before the bottom of the eighth inning. The Bronx Bombers were looking to redeem themselves after blowing their first-inning lead to the Rockies on Friday.But just before the bottom of the eighth inning began, the game was briefly delayed. The Yankees were headed to the field, while the Rockies were preparing to bat. Jones, Trejo hit 11th-inning home runs, lifting NL-worst Rockies over Yankees 8-7 A fan emerged from left field and ran towards Yankees shortstop Anthony Volpe. Photos captured by the Associated Press show the fan throwing what appears to be a white T-shirt at Volpe.Within just a few moments, the fan was wrestled to the ground by a handful of Coors Field security personnel.Field guards bring dow...

Alzheimer's drug promises to slow worsening but with safety concern

Published Wed, 27 Nov 2024 09:22:03 GMT

WASHINGTON (AP) — Another experimental Alzheimer’s drug can modestly slow patients’ inevitable worsening — by about four to seven months, researchers reported Monday.Eli Lilly and Co. is seeking Food and Drug Administration approval of donanemab. If cleared, it would be only the second Alzheimer’s treatment convincingly shown to delay the mind-robbing disease — after the recently approved Leqembi from Japanese drugmaker Eisai. Law enforcement trade Taylor Swift friendship bracelets at Denver Eras Tour stop “Finally there's some hope, right, that we can talk about," Lilly's Dr. John Sims told reporters Monday at the Alzheimer's Association International Conference in Amsterdam. “We don't cure the disease,” he said. “Diabetes doesn't have a cure either — it doesn't mean you can't have very meaningful treatments for patients.”Lilly announced in May that donanemab appeared to work, but on Monday the full results of a study of 1,700 patients was published by the Journal of the American...

Police search for purse thief in Miramar

Published Wed, 27 Nov 2024 09:22:03 GMT

A purse thief was caught on camera in Miramar.Video from Wednesday morning showed a person getting out of a car at a gas station, located at o 3100 SW 148th Ave.The suspect was seen opening the victim’s door, reached inside and took the purse that was on the passenger seat.Police posted video on social media.7News has reached out to police for more information. They have not identified the suspect. If you have any information on this crime, call Broward County Crime Stoppers at 954-493-TIPS. Remember, you can always remain anonymous, and you may be eligible for a reward of up to $5,000.

Ben Wallace is quitting as UK defense secretary. Here’s who might replace him

Published Wed, 27 Nov 2024 09:22:03 GMT

LONDON — Ben Wallace is on the way out as U.K. defense secretary. Attention is already turning to who comes next.Wallace — whose international reputation has been bolstered by the war in Ukraine — announced in a Sunday Times interview that he will resign as defense chief and eventually quit British politics altogether.The jostling to replace him has already started — with prominent Tories well aware that helming the Ministry of Defence during war-time can do wonders for your reputation. Here are the runners and riders to be the next person in charge of U.K. defense.John GlenMuch of Wallace’s tenure was marked by tension between the MoD — pushing to increase capacity — and the bean counters at the Treasury, determined to keep the country’s multibillion-pound defense budget in check.Prime Minister Rishi Sunak could always resolve that tension by … installing a bean counter at the MoD. One name in the frame is John Glen, currently second-in-command to Chancellor Jerem...

Second Alzheimer’s drug to slow disease’s progression may be approved in the US this year

Published Wed, 27 Nov 2024 09:22:03 GMT

(CNN) — The full approval this month of the Alzheimer’s drug Leqembi marked a historic shift in the treatment of the disease: For the first time, doctors have a medicine to prescribe that has been proven to slow the loss of memory and ability to do daily tasks that Alzheimer’s brings.A second drug may join Leqembi — known as lecanemab before it got its brand name — on the market by the end of the year: Eli Lilly’s donanemab.It was shown in May and in fuller Phase 3 clinical trial results released at the Alzheimer’s Association International Conference on Monday to delay the disease’s progression. Lilly said in a news release that it had completed its US Food and Drug Administration submission for the drug, and expects regulatory action by year’s end.More than 6 million Americans are estimated to have Alzheimer’s disease, with about 1 million estimated to be in the early symptomatic stages where these drugs have shown benefit. But even though the medicines ar...

Spotlight on judge in Trump documents case intensifies following controversial earlier ruling

Published Wed, 27 Nov 2024 09:22:03 GMT

By ERIC TUCKER and ADRIANA GOMEZ LICON (Associated Press)MIAMI (AP) — A month after former President Donald Trump was charged with mishandling classified documents, the judge presiding over the case is set to take on a more visible role as she weighs competing requests on a trial date and hears arguments this week on a procedural, but potentially crucial, area of the law.A pretrial conference Tuesday to discuss procedures for handling classified information will represent the first courtroom arguments in the case before U.S. District Judge Aileen Cannon since Trump was indicted five weeks ago. The arguments could provide insight into how Cannon intends to preside over the case while she also confronts the unresolved question of how to schedule Trump’s trial as he campaigns for president.Those issues would be closely watched in any trial involving a former president. But Cannon could face additional scrutiny in light of a much-dissected ruling she issued last year that gr...

Mets outlast rain, walk-off Dodgers in 10 innings

Published Wed, 27 Nov 2024 09:22:03 GMT

It took a four-hour rain delay and extra innings, but the Mets managed to salvage a series against the Los Angeles Dodgers on Sunday afternoon at Citi Field with a 2-1 walk-off win.Luis Guillorme pinch-hit to lead off the 10th with the Mets sending him out to bunt. His first two went foul against right-hander Nick Robertson (0-1), but it didn’t matter. He ripped a double down the right side to score the automatic runner and halt the Mets’ losing streak at four games.“The bunt didn’t really work,” Guillorme said. “Then he just threw one in to me and I tried to get out of the way but that didn’t work out either. All I was trying to do was get a ground ball to the right side. It worked out.”Max Scherzer pitched seven innings of one-hit baseball against his former team, holding them scoreless while striking out six and walking three in a performance that manager Buck Showalter called “outstanding.”Scherzer finally managed to ge...